Instability of aquaglyceroporin (AQP) 2 contributes to drug resistance in Trypanosoma brucei

Defining mode of action is vital for both developing new drugs and predicting potential resistance mechanisms. Sensitivity of African trypanosomes to pentamidine and melarsoprol is predominantly mediated by aquaglyceroporin 2 (TbAQP2), a channel associated with water/glycerol transport. TbAQP2 is ex...

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Detalles Bibliográficos
Autores principales: Quintana, Juan F., Bueren-Calabuig, Juan, Zuccotto, Fabio, de Koning, Harry P., Horn, David, Field, Mark C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413563/
https://www.ncbi.nlm.nih.gov/pubmed/32644992
http://dx.doi.org/10.1371/journal.pntd.0008458

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413563/
https://www.ncbi.nlm.nih.gov/pubmed/32644992
http://dx.doi.org/10.1371/journal.pntd.0008458

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