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Molecular principles of assembly, activation, and inhibition in epithelial sodium channel

The molecular bases of heteromeric assembly and link between Na(+) self-inhibition and protease-sensitivity in epithelial sodium channels (ENaCs) are not fully understood. Previously, we demonstrated that ENaC subunits – α, β, and γ – assemble in a counterclockwise configuration when viewed from out...

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Detalles Bibliográficos
Autores principales: Noreng, Sigrid, Posert, Richard, Bharadwaj, Arpita, Houser, Alexandra, Baconguis, Isabelle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7413742/
https://www.ncbi.nlm.nih.gov/pubmed/32729833
http://dx.doi.org/10.7554/eLife.59038