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Inefficient V(D)J recombination underlies monogenic T cell receptor β expression

The assembly of T cell receptor (TCR) and immunoglobulin (Ig) genes by V(D)J recombination generates the antigen receptor (AgR) diversity that is vital for adaptive immunity. At most AgR loci, V(D)J recombination is regulated so that only one allele assembles a functional gene, ensuring that nearly...

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Detalles Bibliográficos
Autores principales: Wu, Glendon S., Bassing, Craig H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414081/
https://www.ncbi.nlm.nih.gov/pubmed/32690689
http://dx.doi.org/10.1073/pnas.2010077117