Investigation of alpl expression and Tnap-activity in zebrafish implies conserved functions during skeletal and neuronal development

Hypophosphatasia (HPP) is a rare genetic disease with diverse symptoms and a heterogeneous severity of onset with underlying mutations in the ALPL gene encoding the ectoenzyme Tissue-nonspecific alkaline phosphatase (TNAP). Considering the establishment of zebrafish (Danio rerio) as a new model orga...

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Detalles Bibliográficos
Autores principales: Ohlebusch, Barbara, Borst, Angela, Frankenbach, Tina, Klopocki, Eva, Jakob, Franz, Liedtke, Daniel, Graser, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414108/
https://www.ncbi.nlm.nih.gov/pubmed/32770041
http://dx.doi.org/10.1038/s41598-020-70152-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414108/
https://www.ncbi.nlm.nih.gov/pubmed/32770041
http://dx.doi.org/10.1038/s41598-020-70152-5

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