Metformin inhibits RAN translation through PKR pathway and mitigates disease in C9orf72 ALS/FTD mice

Repeat associated non-AUG (RAN) translation is found in a growing number of microsatellite expansion diseases, but the mechanisms remain unclear. We show that RAN translation is highly regulated by the double-stranded RNA-dependent protein kinase (PKR). In cells, structured CAG, CCUG, CAGG, and G(4)...

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Detalles Bibliográficos
Autores principales: Zu, Tao, Guo, Shu, Bardhi, Olgert, Ryskamp, Daniel A., Li, Jian, Khoramian Tusi, Solaleh, Engelbrecht, Avery, Klippel, Kelena, Chakrabarty, Paramita, Nguyen, Lien, Golde, Todd E., Sonenberg, Nahum, Ranum, Laura P. W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414156/
https://www.ncbi.nlm.nih.gov/pubmed/32690681
http://dx.doi.org/10.1073/pnas.2005748117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414156/
https://www.ncbi.nlm.nih.gov/pubmed/32690681
http://dx.doi.org/10.1073/pnas.2005748117

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