Last step in the path of LDL cholesterol from lysosome to plasma membrane to ER is governed by phosphatidylserine

Animal cells acquire cholesterol from receptor-mediated uptake of low-density lipoprotein (LDL), which releases cholesterol in lysosomes. The cholesterol moves to the endoplasmic reticulum (ER), where it inhibits production of LDL receptors, completing a feedback loop. Here we performed a CRISPR-Cas...

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Detalles Bibliográficos
Autores principales: Trinh, Michael N., Brown, Michael S., Goldstein, Joseph L., Han, Jaeil, Vale, Gonçalo, McDonald, Jeffrey G., Seemann, Joachim, Mendell, Joshua T., Lu, Feiran
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414171/
https://www.ncbi.nlm.nih.gov/pubmed/32690708
http://dx.doi.org/10.1073/pnas.2010682117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414171/
https://www.ncbi.nlm.nih.gov/pubmed/32690708
http://dx.doi.org/10.1073/pnas.2010682117

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