Nanoparticles presenting clusters of CD4 expose a universal vulnerability of HIV-1 by mimicking target cells

CD4-based decoy approaches against HIV-1 are attractive options for long-term viral control, but initial designs, including soluble CD4 (sCD4) and CD4-Ig, were ineffective. To evaluate a therapeutic that more accurately mimics HIV-1 target cells compared with monomeric sCD4 and dimeric CD4-Ig, we ge...

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Detalles Bibliográficos
Autores principales: Hoffmann, Magnus A. G., Bar-On, Yotam, Yang, Zhi, Gristick, Harry B., Gnanapragasam, Priyanthi N. P., Vielmetter, Jost, Nussenzweig, Michel C., Bjorkman, Pamela J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414181/
https://www.ncbi.nlm.nih.gov/pubmed/32690692
http://dx.doi.org/10.1073/pnas.2010320117

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414181/
https://www.ncbi.nlm.nih.gov/pubmed/32690692
http://dx.doi.org/10.1073/pnas.2010320117

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