Structure-based evolution of a promiscuous inhibitor to a selective stabilizer of protein–protein interactions

The systematic stabilization of protein–protein interactions (PPI) has great potential as innovative drug discovery strategy to target novel and hard-to-drug protein classes. The current lack of chemical starting points and focused screening opportunities limits the identification of small molecule...

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Detalles Bibliográficos
Autores principales: Sijbesma, Eline, Visser, Emira, Plitzko, Kathrin, Thiel, Philipp, Milroy, Lech-Gustav, Kaiser, Markus, Brunsveld, Luc, Ottmann, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414219/
https://www.ncbi.nlm.nih.gov/pubmed/32770072
http://dx.doi.org/10.1038/s41467-020-17741-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414219/
https://www.ncbi.nlm.nih.gov/pubmed/32770072
http://dx.doi.org/10.1038/s41467-020-17741-0

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