2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705

Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2’-fluoro-2’-deoxycytidine (2’-FdC) has been reported to have broad antiviral activity....

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Autores principales: Yu, Peifa, Wang, Yining, Li, Yunlong, Li, Yang, Miao, Zhijiang, Peppelenbosch, Maikel P., Pan, Qiuwei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414258/
https://www.ncbi.nlm.nih.gov/pubmed/32770483
http://dx.doi.org/10.1007/s00705-020-04759-4
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author Yu, Peifa
Wang, Yining
Li, Yunlong
Li, Yang
Miao, Zhijiang
Peppelenbosch, Maikel P.
Pan, Qiuwei
author_facet Yu, Peifa
Wang, Yining
Li, Yunlong
Li, Yang
Miao, Zhijiang
Peppelenbosch, Maikel P.
Pan, Qiuwei
author_sort Yu, Peifa
collection PubMed
description Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2’-fluoro-2’-deoxycytidine (2’-FdC) has been reported to have broad antiviral activity. Here, we report that 2’-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation of cytidine triphosphate. The combination of 2’-FdC with mycophenolic acid, ribavirin or favipiravir (T705) exerts synergistic antiviral effects. These results indicate that 2’-FdC is a potential candidate for antiviral drug development against norovirus infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-020-04759-4) contains supplementary material, which is available to authorized users.
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spelling pubmed-74142582020-08-10 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705 Yu, Peifa Wang, Yining Li, Yunlong Li, Yang Miao, Zhijiang Peppelenbosch, Maikel P. Pan, Qiuwei Arch Virol Brief Report Noroviruses are the main causative agents of acute viral gastroenteritis worldwide. However, no vaccine or specific antiviral treatment is available, imposing a heavy global health burden. The nucleoside analogue 2’-fluoro-2’-deoxycytidine (2’-FdC) has been reported to have broad antiviral activity. Here, we report that 2’-FdC significantly inhibits murine norovirus replication in macrophages. This effect was partially reversed by exogenous supplementation of cytidine triphosphate. The combination of 2’-FdC with mycophenolic acid, ribavirin or favipiravir (T705) exerts synergistic antiviral effects. These results indicate that 2’-FdC is a potential candidate for antiviral drug development against norovirus infection. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00705-020-04759-4) contains supplementary material, which is available to authorized users. Springer Vienna 2020-08-08 2020 /pmc/articles/PMC7414258/ /pubmed/32770483 http://dx.doi.org/10.1007/s00705-020-04759-4 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Brief Report
Yu, Peifa
Wang, Yining
Li, Yunlong
Li, Yang
Miao, Zhijiang
Peppelenbosch, Maikel P.
Pan, Qiuwei
2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title_full 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title_fullStr 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title_full_unstemmed 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title_short 2’-Fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes MPA, ribavirin and T705
title_sort 2’-fluoro-2’-deoxycytidine inhibits murine norovirus replication and synergizes mpa, ribavirin and t705
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414258/
https://www.ncbi.nlm.nih.gov/pubmed/32770483
http://dx.doi.org/10.1007/s00705-020-04759-4
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