Using whole-genome sequencing data to derive the homologous recombination deficiency scores

The homologous recombination deficiency (HRD) score was developed using whole-genome copy number data derived from arrays as a way to infer deficiency in the homologous recombination DNA damage repair pathway (in particular BRCA1 or BRCA2 deficiency) in breast cancer samples. The score has utility i...

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Detalles Bibliográficos
Autores principales: de Luca, Xavier M., Newell, Felicity, Kazakoff, Stephen H., Hartel, Gunter, McCart Reed, Amy E., Holmes, Oliver, Xu, Qinying, Wood, Scott, Leonard, Conrad, Pearson, John V., Lakhani, Sunil R., Waddell, Nicola, Nones, Katia, Simpson, Peter T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414867/
https://www.ncbi.nlm.nih.gov/pubmed/32818150
http://dx.doi.org/10.1038/s41523-020-0172-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414867/
https://www.ncbi.nlm.nih.gov/pubmed/32818150
http://dx.doi.org/10.1038/s41523-020-0172-0

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