Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

The aggregation of the intrinsically disordered tau protein into highly ordered β-sheet-rich fibrils is implicated in the pathogenesis of a range of neurodegenerative disorders. The mechanism of tau fibrillogenesis remains unresolved, particularly early events that trigger the misfolding and assembl...

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Detalles Bibliográficos
Autores principales: Majewski, Jaroslaw, Jones, Emmalee M., Vander Zanden, Crystal M., Biernat, Jacek, Mandelkow, Eckhard, Chi, Eva Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414892/
https://www.ncbi.nlm.nih.gov/pubmed/32770092
http://dx.doi.org/10.1038/s41598-020-70208-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414892/
https://www.ncbi.nlm.nih.gov/pubmed/32770092
http://dx.doi.org/10.1038/s41598-020-70208-6

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