Cargando…

Lipid membrane templated misfolding and self-assembly of intrinsically disordered tau protein

The aggregation of the intrinsically disordered tau protein into highly ordered β-sheet-rich fibrils is implicated in the pathogenesis of a range of neurodegenerative disorders. The mechanism of tau fibrillogenesis remains unresolved, particularly early events that trigger the misfolding and assembl...

Descripción completa

Detalles Bibliográficos
Autores principales:	Majewski, Jaroslaw, Jones, Emmalee M., Vander Zanden, Crystal M., Biernat, Jacek, Mandelkow, Eckhard, Chi, Eva Y.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7414892/ https://www.ncbi.nlm.nih.gov/pubmed/32770092 http://dx.doi.org/10.1038/s41598-020-70208-6

Ejemplares similares

Tau and Membranes: Interactions That Promote Folding and Condensation
por: Sallaberry, Chad A., et al.
Publicado: (2021)

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
por: Kaniyappan, Senthilvelrajan, et al.
Publicado: (2020)

Disease‐Associated Tau Phosphorylation Hinders Tubulin Assembly within Tau Condensates
por: Savastano, Adriana, et al.
Publicado: (2020)

A combinatorial native MS and LC-MS/MS approach reveals high intrinsic phosphorylation of human Tau but minimal levels of other key modifications
por: Drepper, Friedel, et al.
Publicado: (2021)

Stages and Conformations of the Tau Repeat Domain during Aggregation and Its Effect on Neuronal Toxicity
por: Kumar, Satish, et al.
Publicado: (2014)

Liquid–liquid phase separation of the microtubule-binding repeats of the Alzheimer-related protein Tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2017)

Oligomer Formation of Tau Protein Hyperphosphorylated in Cells
por: Tepper, Katharina, et al.
Publicado: (2014)

Residue-specific identification of phase separation hot spots of Alzheimer's-related protein tau
por: Ambadipudi, Susmitha, et al.
Publicado: (2019)

Multivalent cross-linking of actin filaments and microtubules through the microtubule-associated protein Tau
por: Cabrales Fontela, Yunior, et al.
Publicado: (2017)

Unbiased proteomic profiling reveals the IP3R modulator AHCYL1/IRBIT as a novel interactor of microtubule-associated protein tau
por: Wischhof, Lena, et al.
Publicado: (2022)

Structural Polymorphism of 441-Residue Tau at Single Residue Resolution
por: Mukrasch, Marco D, et al.
Publicado: (2009)

Inhibition of Tau aggregation with BSc3094 reduces Tau and decreases cognitive deficits in rTg4510 mice
por: Anglada‐Huguet, Marta, et al.
Publicado: (2021)

Suppressing Tau Aggregation and Toxicity by an Anti-Aggregant Tau Fragment
por: Pir, Ghulam Jeelani, et al.
Publicado: (2018)

Anti-aggregant tau mutant promotes neurogenesis
por: Joseph, Maria, et al.
Publicado: (2017)

Structure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein
por: Timm, Thomas, et al.
Publicado: (2008)

Domains of Neuronal Microtubule-associated Proteins and Flexural Rigidity of Microtubules
por: Felgner, Harald, et al.
Publicado: (1997)

Extracellular Monomeric Tau Protein Is Sufficient to Initiate the Spread of Tau Protein Pathology
por: Michel, Claire H., et al.
Publicado: (2014)

Templated misfolding of Tau by prion-like seeding along neuronal connections impairs neuronal network function and associated behavioral outcomes in Tau transgenic mice
por: Stancu, Ilie-Cosmin, et al.
Publicado: (2015)

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein
por: Janssen, Kobe, et al.
Publicado: (2023)

Tau mutant A152T, a risk factor for FTD/PSP, induces neuronal dysfunction and reduced lifespan independently of aggregation in a C. elegans Tauopathy model
por: Pir, Ghulam Jeelani, et al.
Publicado: (2016)

MARK/PAR1 kinase is a regulator of microtubule-dependent transport in axons
por: Mandelkow, Eva-Maria, et al.
Publicado: (2004)

Different tau species lead to heterogeneous tau pathology propagation and misfolding
por: Dujardin, Simon, et al.
Publicado: (2018)

Pro-aggregant Tau impairs mossy fiber plasticity due to structural changes and Ca(++) dysregulation
por: Decker, Jochen Martin, et al.
Publicado: (2015)

Interplay of pathogenic forms of human tau with different autophagic pathways
por: Caballero, Benjamin, et al.
Publicado: (2017)

The Role of Protein Misfolding and Tau Oligomers (TauOs) in Alzheimer’s Disease (AD)
por: Mroczko, Barbara, et al.
Publicado: (2019)

The release and trans-synaptic transmission of Tau via exosomes
por: Wang, Yipeng, et al.
Publicado: (2017)

Functional networks are impaired by elevated tau-protein but reversible in a regulatable Alzheimer’s disease mouse model
por: Green, Claudia, et al.
Publicado: (2019)

Identification of Small Molecule Inhibitors of Tau Aggregation by Targeting Monomeric Tau As a Potential Therapeutic Approach for Tauopathies
por: Pickhardt, Marcus, et al.
Publicado: (2015)

DNA-nanostructure-templated assembly of planar and curved lipid-bilayer membranes
por: Elbahnasawy, Mostafa A., et al.
Publicado: (2023)

Proteasomal degradation of the intrinsically disordered protein tau at single-residue resolution
por: Ukmar-Godec, T., et al.
Publicado: (2020)

What is the evidence that tau pathology spreads through prion-like propagation?
por: Mudher, Amrit, et al.
Publicado: (2017)

Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex
por: Oroz, Javier, et al.
Publicado: (2018)

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers
por: Shammas, Sarah L., et al.
Publicado: (2015)

Reversal of Tau-Dependent Cognitive Decay by Blocking Adenosine A1 Receptors: Comparison of Transgenic Mouse Models with Different Levels of Tauopathy
por: Anglada-Huguet, Marta, et al.
Publicado: (2023)

Acetylation mimic of lysine 280 exacerbates human Tau neurotoxicity in vivo
por: Gorsky, Marianna Karina, et al.
Publicado: (2016)

Selective Detection of Misfolded Tau From Postmortem Alzheimer’s Disease Brains
por: Wu, Ling, et al.
Publicado: (2022)

The Role of Lipids in the Initiation of α-Synuclein Misfolding
por: Kiechle, Martin, et al.
Publicado: (2020)

Solid-state NMR investigation of the involvement of the P2 region in tau amyloid fibrils
por: Savastano, Adriana, et al.
Publicado: (2020)

Preventive methylene blue treatment preserves cognition in mice expressing full-length pro-aggregant human Tau
por: Hochgräfe, Katja, et al.
Publicado: (2015)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_jvdom6kitrcr6dfgetti5o94cr