Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma

BACKGROUND: Polyglutamylation is a reversible protein modification that commonly occurs in tumor cells. Methotrexate (MTX) in tumor cells is polyglutamylated and strongly binds to dihydrofolate reductase (DHFR) without competitive inhibition by leucovorin. Therefore, tumor cells with high polyglutam...

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Detalles Bibliográficos
Autores principales: Fujimoto, Kenji, Shinojima, Naoki, Hayashi, Mitsuhiro, Nakano, Tomoyuki, Ichimura, Koichi, Mukasa, Akitake
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Basic and Translational Investigations
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415262/
https://www.ncbi.nlm.nih.gov/pubmed/32793886
http://dx.doi.org/10.1093/noajnl/vdaa084

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415262/
https://www.ncbi.nlm.nih.gov/pubmed/32793886
http://dx.doi.org/10.1093/noajnl/vdaa084

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