Cargando…

Histone deacetylase inhibition enhances the therapeutic effects of methotrexate on primary central nervous system lymphoma

BACKGROUND: Polyglutamylation is a reversible protein modification that commonly occurs in tumor cells. Methotrexate (MTX) in tumor cells is polyglutamylated and strongly binds to dihydrofolate reductase (DHFR) without competitive inhibition by leucovorin. Therefore, tumor cells with high polyglutam...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fujimoto, Kenji, Shinojima, Naoki, Hayashi, Mitsuhiro, Nakano, Tomoyuki, Ichimura, Koichi, Mukasa, Akitake
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Basic and Translational Investigations
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415262/ https://www.ncbi.nlm.nih.gov/pubmed/32793886 http://dx.doi.org/10.1093/noajnl/vdaa084

Ejemplares similares

Effects of valproic acid on histone deacetylase inhibition in vitro and in glioblastoma patient samples
por: Berendsen, Sharon, et al.
Publicado: (2019)

ML-20 Outcome of high-dose methotrexate-based chemotherapy with or without Rituximab for primary central nervous system lymphoma
por: Takezaki, Tatsuya, et al.
Publicado: (2020)

ML-15 The future direction of treatment development for primary central nervous system lymphoma (PCNSL)
por: Shinojima, Naoki, et al.
Publicado: (2020)

Histone deacetylase inhibitors enhance estrogen receptor beta expression and augment agonist-mediated tumor suppression in glioblastoma
por: Pratap, Uday P, et al.
Publicado: (2021)

Clinical significance of polyglutamylation in primary central nervous system lymphoma
por: Shinojima, Naoki, et al.
Publicado: (2018)

Use of rituximab, temozolomide, and radiation in recurrent and refractory primary central nervous system lymphoma in the Philippines: a retrospective analysis
por: Batara, Julette Marie F, et al.
Publicado: (2022)

Chromosome 17 alterations identify good-risk and poor-risk tumors independently of clinical factors in medulloblastoma
por: McCabe, Martin G., et al.
Publicado: (2011)

Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes
por: Angiolilli, Chiara, et al.
Publicado: (2017)

EPID-01. TRENDS OF INCIDENCE IN PEDIATRIC BRAIN TUMORS IN KUMAMOTO PREFECTURE, JAPAN
por: Itoyama, Takashi, et al.
Publicado: (2020)

EPEN-02. EVALUATION OF TREATMENT OUTCOMES AND EXPRESSION OF EMT-RELATED TRANSCRIPTION FACTORS AS NOVEL THERAPEUTIC TARGETS IN PEDIATRIC EPENDYMOMA
por: Makino, Keishi, et al.
Publicado: (2020)

Clinical utility of comprehensive genomic profiling in central nervous system tumors of children and young adults
por: Ji, Jianling, et al.
Publicado: (2021)

Histone deacetylase inhibitors suppress rheumatoid arthritis fibroblast-like synoviocyte and macrophage IL-6 production by accelerating mRNA decay
por: Grabiec, Aleksander M, et al.
Publicado: (2011)

Primary CNS lymphoma commonly expresses immune response biomarkers
por: Ou, Alexander, et al.
Publicado: (2020)

An EZH2 blocker sensitizes histone mutated diffuse midline glioma to cholesterol metabolism inhibitors through an off-target effect
por: Rahal, Farah, et al.
Publicado: (2022)

COT-18 Trends in Primary Brain Tumors in Kumamoto Prefecture with Declining Birthrate and Aging Population - Kumamoto Prefecture Brain Tumor Epidemiological Survey
por: Shinojima, Naoki, et al.
Publicado: (2021)

Raised cardiovascular disease mortality after central nervous system tumor diagnosis: analysis of 171,926 patients from UK and USA
por: Jin, Kai, et al.
Publicado: (2021)

Early-onset grade 2-3 diffuse gliomas and schwannomas increase the risk of central nervous system tumors among the patients’ relatives
por: Alanen, Eljas, et al.
Publicado: (2023)

Rare central nervous system tumors in adults: a population-based study of ependymomas, pilocytic astrocytomas, medulloblastomas, and intracranial germ cell tumors
por: Ho, Vincent K Y, et al.
Publicado: (2022)

Low-pass whole-genome and targeted sequencing of cell-free DNA from cerebrospinal fluid in pediatric patients with central nervous system tumors
por: O’Halloran, Katrina, et al.
Publicado: (2023)

Radiomic features define risk and are linked to DNA methylation attributes in primary CNS lymphoma
por: Nenning, Karl-Heinz, et al.
Publicado: (2023)

Incidence trends in pediatric central nervous system tumors in Canada: a 15 years report from Cancer and Young People in Canada (CYP-C) registry
por: Larouche, Valérie, et al.
Publicado: (2020)

Clinical utility of whole-genome DNA methylation profiling as a primary molecular diagnostic assay for central nervous system tumors—A prospective study and guidelines for clinical testing
por: Galbraith, Kristyn, et al.
Publicado: (2023)

ML-03 RECONSIDERATION OF TREATMENT FOR ELDERLY PATIENTS WITH PRIMARY CENTRAL NERVE SYSTEM LYMPHOMAS
por: Shinojima, Naoki, et al.
Publicado: (2019)

Identification of glioblastoma-specific antigens expressed in patient-derived tumor cells as candidate targets for chimeric antigen receptor T cell therapy
por: Nakagawa, Tomoyoshi, et al.
Publicado: (2022)

Gene expression-based prediction of myeloma cell sensitivity to histone deacetylase inhibitors
por: Moreaux, J, et al.
Publicado: (2013)

Methotrexate limits inflammation through an A20-dependent cross-tolerance mechanism
por: Municio, Cristina, et al.
Publicado: (2018)

Downregulation of PD-L1 via FKBP5 by celecoxib augments antitumor effects of PD-1 blockade in a malignant glioma model
por: Yamaguchi, Izumi, et al.
Publicado: (2019)

Tumor edge-to-core transition promotes malignancy in primary-to-recurrent glioblastoma progression in a PLAGL1/CD109-mediated mechanism
por: Li, Chaoxi, et al.
Publicado: (2020)

Distinct difference in tumor-infiltrating immune cells between Wilms’ tumor gene 1 peptide vaccine and anti-programmed cell death-1 antibody therapies
por: Yokota, Chisato, et al.
Publicado: (2021)

p53-dependent and p53-independent anticancer effects of different histone deacetylase inhibitors
por: Sonnemann, J, et al.
Publicado: (2014)

ML-17 Clinical usefulness of Tirabrutinib in recurrent PCNSL: single institute experience
por: Matsuura, Jin, et al.
Publicado: (2021)

Methotrexate-mediated activation of an AMPK-CREB-dependent pathway: a novel mechanism for vascular protection in chronic systemic inflammation
por: Thornton, C C, et al.
Publicado: (2016)

GCT-36. TREATMENT RESULTS AND RADIATION-INDUCED TUMORS IN CASES OF CENTRAL NERVOUS SYSTEM GERM CELL TUMOR: A LONG-TERM FOLLOW-UP STUDY IN KUMAMOTO PREFECTURE
por: Yamamoto, Takahiro, et al.
Publicado: (2020)

Histone deacetylase inhibitors in Hodgkin lymphoma
por: Buglio, Daniela, et al.
Publicado: (2010)

Effect of a Histone Deacetylases Inhibitor of IL-18 and TNF-Alpha Secretion in Vitro
por: Dobreva, Zlatka Georgieva, et al.
Publicado: (2018)

Signaling Network Response to α-Particle–Targeted Therapy with the (225)Ac-Labeled Minigastrin Analog (225)Ac-PP-F11N Reveals the Radiosensitizing Potential of Histone Deacetylase Inhibitors
por: Qin, Yun, et al.
Publicado: (2023)

Atypical pituitary abscess lacking rim enhancement and diffusion restriction with an unusual organism, Moraxella catarrhalis: A case report and review of the literature
por: Kawano, Tatsuya, et al.
Publicado: (2021)

Hypoxia-independent gene expression signature associated with radiosensitisation of prostate cancer cell lines by histone deacetylase inhibition
por: Jonsson, Marte, et al.
Publicado: (2016)

Osteopontin regulates human glioma cell invasiveness and tumor growth in mice
por: Jan, Hsun-Jin, et al.
Publicado: (2010)

Tumor invasion after treatment of glioblastoma with bevacizumab: radiographic and pathologic correlation in humans and mice
por: de Groot, John F., et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_2u5itmqdeu1il851b1lqas3rp4