Rare Genetic Variants in Complement Factor I Lead to Low FI Plasma Levels Resulting in Increased Risk of Age-Related Macular Degeneration

PURPOSE: Rare genetic variants in complement factor I (CFI) that cause low systemic levels of the protein (FI) have been reported as a strong risk factor for advanced age-related macular degeneration (AMD). This study set out to replicate these findings. METHODS: FI levels were measured by sandwich...

Descripción completa

Detalles Bibliográficos
Autores principales: Hallam, Thomas M., Marchbank, Kevin J., Harris, Claire L., Osmond, Clive, Shuttleworth, Victoria G., Griffiths, Helen, Cree, Angela J., Kavanagh, David, Lotery, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Genetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415286/
https://www.ncbi.nlm.nih.gov/pubmed/32516404
http://dx.doi.org/10.1167/iovs.61.6.18

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415286/
https://www.ncbi.nlm.nih.gov/pubmed/32516404
http://dx.doi.org/10.1167/iovs.61.6.18

Ejemplares similares