Cargando…

Prostaglandin F2α Agonists Negatively Modulate the Size of 3D Organoids from Primary Human Orbital Fibroblasts

PURPOSE: To elucidate the molecular etiology of deepening of the upper eyelid sulcus (DUES) induced by prostaglandin (PG) analogs, a three-dimensional (3D) tissue culture system was employed using human orbital fibroblasts (HOFs). METHODS: During adipogenesis, changes in HOF 3D organoid sizes, as we...

Descripción completa

Detalles Bibliográficos
Autores principales:	Itoh, Kaku, Hikage, Fumihito, Ida, Yosuke, Ohguro, Hiroshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Glaucoma
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415291/ https://www.ncbi.nlm.nih.gov/pubmed/32503053 http://dx.doi.org/10.1167/iovs.61.6.13

Ejemplares similares

Prostaglandin F2α agonists induced enhancement in collagen1 expression is involved in the pathogenesis of the deepening of upper eyelid sulcus
por: Itoh, Kaku, et al.
Publicado: (2021)

Prostaglandin F2α agonist-induced suppression of 3T3-L1 cell adipogenesis affects spatial formation of extra-cellular matrix
por: Ida, Yosuke, et al.
Publicado: (2020)

Omidenepag, a Selective, Prostanoid EP2 Agonist, Does Not Suppress Adipogenesis in 3D Organoids of Human Orbital Fibroblasts
por: Hikage, Fumihito, et al.
Publicado: (2021)

Prostaglandin F2 and EP2 Agonists Exert Different Effects on 3D 3T3-L1 Spheroids during Their Culture Phase
por: Ida, Yosuke, et al.
Publicado: (2021)

Omidenepag, a non-prostanoid EP2 receptor agonist, induces enlargement of the 3D organoid of 3T3-L1 cells
por: Ida, Yosuke, et al.
Publicado: (2020)

Reactivities of a Prostanoid EP2 Agonist, Omidenepag, Are Useful for Distinguishing between 3D Spheroids of Human Orbital Fibroblasts without or with Graves’ Orbitopathy
por: Ida, Yosuke, et al.
Publicado: (2021)

ROCK inhibitors enhance the production of large lipid-enriched 3D organoids of 3T3-L1 cells
por: Ida, Yosuke, et al.
Publicado: (2021)

Screening of the Drug-Induced Effects of Prostaglandin EP2 and FP Agonists on 3D Cultures of Dexamethasone-Treated Human Trabecular Meshwork Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

ROCK inhibitors modulate the physical properties and adipogenesis of 3D spheroids of human orbital fibroblasts in different manners
por: Hikage, Fumihito, et al.
Publicado: (2021)

ROCK inhibitors beneficially alter the spatial configuration of TGFβ2-treated 3D organoids from a human trabecular meshwork (HTM)
por: Ota, Chiaki, et al.
Publicado: (2020)

Rosiglitasone and ROCK Inhibitors Modulate Fibrogenetic Changes in TGF-β2 Treated Human Conjunctival Fibroblasts (HconF) in Different Manners
por: Oouchi, Yuika, et al.
Publicado: (2021)

Simultaneous Use of ROCK Inhibitors and EP2 Agonists Induces Unexpected Effects on Adipogenesis and the Physical Properties of 3T3-L1 Preadipocytes
por: Ida, Yosuke, et al.
Publicado: (2021)

Detection of significantly high vitreous concentrations of fatty acid-binding protein 4 in patients with proliferative diabetic retinopathy
por: Itoh, Kaku, et al.
Publicado: (2021)

Fatty acid-binding protein 4 is an independent factor in the pathogenesis of retinal vein occlusion
por: Hikage, Fumihito, et al.
Publicado: (2021)

Addition of ROCK Inhibitors Alleviates Prostaglandin-Induced Inhibition of Adipogenesis in 3T3L-1 Spheroids
por: Ida, Yosuke, et al.
Publicado: (2022)

Association between personality traits and experience of adverse periocular reactions to topical prostaglandin analogues
por: Kishimoto, Nanami, et al.
Publicado: (2022)

Influence of a Prostaglandin F2α Analogue on Corneal Hysteresis and Expression of Extracellular Matrix Metalloproteinases 3 and 9
por: Weber, Constance, et al.
Publicado: (2023)

Modulation of the Physical Properties of 3D Spheroids Derived from Human Scleral Stroma Fibroblasts (HSSFs) with Different Axial Lengths Obtained from Surgical Patients
por: Katayama, Hiroyasu, et al.
Publicado: (2021)

Benzalkonium Chloride, Even at Low Concentrations, Deteriorates Intracellular Metabolic Capacity in Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Fatty Acid-Binding Proteins 4 and 5 Are Involved in the Pathogenesis of Retinal Vascular Diseases in Different Manners
por: Higashide, Megumi, et al.
Publicado: (2022)

Establishment of appropriate glaucoma models using dexamethasone or TGFβ2 treated three-dimension (3D) cultured human trabecular meshwork (HTM) cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Diverse effects of pan-ROCK and ROCK2 inhibitors on 2 D and 3D cultured human trabecular meshwork (HTM) cells treated with TGFβ2
por: Watanabe, Megumi, et al.
Publicado: (2021)

ROCK 1 and 2 affect the spatial architecture of 3D spheroids derived from human corneal stromal fibroblasts in different manners
por: Ida, Yosuke, et al.
Publicado: (2022)

Comparison of the Drug-Induced Efficacies between Omidenepag Isopropyl, an EP2 Agonist and PGF2α toward TGF-β2-Modulated Human Trabecular Meshwork (HTM) Cells
por: Suzuki, Soma, et al.
Publicado: (2022)

FGF-2 enhances fibrogenetic changes in TGF-β2 treated human conjunctival fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Autotaxin May Have Lysophosphatidic Acid-Unrelated Effects on Three-Dimension (3D) Cultured Human Trabecular Meshwork (HTM) Cells
por: Watanabe, Megumi, et al.
Publicado: (2021)

Pan-ROCK and ROCK2 Inhibitors Affect Dexamethasone-Treated 2D- and 3D-Cultured Human Trabecular Meshwork (HTM) Cells in Opposite Manners
por: Watanabe, Megumi, et al.
Publicado: (2021)

An α2-Adrenergic Agonist, Brimonidine, Beneficially Affects the TGF-β2-Treated Cellular Properties in an In Vitro Culture Model
por: Watanabe, Megumi, et al.
Publicado: (2022)

All Trans-Retinoic Acids Facilitate the Remodeling of 2D and 3D Cultured Human Conjunctival Fibroblasts
por: Tsugeno, Yuri, et al.
Publicado: (2022)

Regional Differences and Physiologic Behaviors in Peripapillary Scleral Fibroblasts
por: Szeto, Julia, et al.
Publicado: (2021)

STAT3 Is the Master Regulator for the Forming of 3D Spheroids of 3T3-L1 Preadipocytes
por: Ohguro, Hiroshi, et al.
Publicado: (2022)

Trabeculotomy opening size and IOP reduction after Trabectome® surgery
por: Wecker, Thomas, et al.
Publicado: (2017)

The Roles Played by FP/EP3 Receptors During Pressure-lowering in Mouse Eyes Mediated by a Dual FP/EP3 Receptor Agonist
por: Yamagishi-Kimura, Reiko, et al.
Publicado: (2022)

Lamina Cribrosa Pore Shape and Size as Predictors of Neural Tissue Mechanical Insult
por: Voorhees, Andrew P., et al.
Publicado: (2017)

The Selective α1 Antagonist Tamsulosin Alters ECM Distributions and Cellular Metabolic Functions of ARPE 19 Cells in a Concentration-Dependent Manner
por: Ida, Yosuke, et al.
Publicado: (2022)

Brimonidine Modulates the ROCK1 Signaling Effects on Adipogenic Differentiation in 2D and 3D 3T3-L1 Cells
por: Umetsu, Araya, et al.
Publicado: (2022)

3D culture induction of adipogenic differentiation in 3T3-L1 preadipocytes exhibits adipocyte-specific molecular expression patterns and metabolic functions
por: Endo, Keisuke, et al.
Publicado: (2023)

ALK5 Inhibition of Subconjunctival Scarring From Glaucoma Surgery: Effects of SB-431542 Compared to Mitomycin C in Human Tenon's Capsule Fibroblasts
por: Teplitsky, Jack E., et al.
Publicado: (2023)

Inhibitory Effects of 3′,4′-Dihydroxyflavonol in a Mouse Model of Glaucoma Filtration Surgery and TGFβ1-Induced Responses in Human Tenon's Fibroblasts
por: Fan Gaskin, Jennifer C., et al.
Publicado: (2022)

The Effective Dynamic Ranges for Glaucomatous Visual Field Progression With Standard Automated Perimetry and Stimulus Sizes III and V
por: Wall, Michael, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_25rp1nnfhtmrs0espiaeh4ovr4