Opa1 Deficiency Leads to Diminished Mitochondrial Bioenergetics With Compensatory Increased Mitochondrial Motility

PURPOSE: Retinal ganglion cells (RGCs) are susceptible to mitochondrial deficits and also the major cell type affected in patients with mutations in the OPA1 gene in autosomal dominant optic atrophy (ADOA). Here, we characterized mitochondria in RGCs in vitro from a heterozygous B6; C3-Opa1(Q285STOP...

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Detalles Bibliográficos
Autores principales: Sun, Shanshan, Erchova, Irina, Sengpiel, Frank, Votruba, Marcela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415319/
https://www.ncbi.nlm.nih.gov/pubmed/32561926
http://dx.doi.org/10.1167/iovs.61.6.42

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415319/
https://www.ncbi.nlm.nih.gov/pubmed/32561926
http://dx.doi.org/10.1167/iovs.61.6.42

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