AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis

PURPOSE: Increased TGF-β1 synthesis after corneal alkali injury is implicated in corneal fibrosis, as it promotes transdifferentiation of keratocytes into myofibroblasts. The activation of 5′-adenosine monophosphate-activated protein kinase (AMPK) by 5-amino-4-imidazole carboxamide riboside-1-β-d-ri...

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Detalles Bibliográficos
Autores principales: Nuwormegbe, Selikem Abla, Kim, Sun Woong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Association for Research in Vision and Ophthalmology 2020
Materias:
Biochemistry and Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415321/
https://www.ncbi.nlm.nih.gov/pubmed/32561924
http://dx.doi.org/10.1167/iovs.61.6.43

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415321/
https://www.ncbi.nlm.nih.gov/pubmed/32561924
http://dx.doi.org/10.1167/iovs.61.6.43

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