Cargando…

AMPK Activation by 5-Amino-4-Imidazole Carboxamide Riboside-1-β-D-Ribofuranoside Attenuates Alkali Injury-Induced Corneal Fibrosis

PURPOSE: Increased TGF-β1 synthesis after corneal alkali injury is implicated in corneal fibrosis, as it promotes transdifferentiation of keratocytes into myofibroblasts. The activation of 5′-adenosine monophosphate-activated protein kinase (AMPK) by 5-amino-4-imidazole carboxamide riboside-1-β-d-ri...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nuwormegbe, Selikem Abla, Kim, Sun Woong
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415321/ https://www.ncbi.nlm.nih.gov/pubmed/32561924 http://dx.doi.org/10.1167/iovs.61.6.43

Ejemplares similares

Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration
por: Zhang, Xian, et al.
Publicado: (2020)

Enhancement of insulin-mediated rat muscle glucose uptake and microvascular perfusion by 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside
por: Bradley, Eloise A, et al.
Publicado: (2015)

5-aminoimidazole-4-carboxamide-1-beta-4-ribofuranoside (AICAR) attenuates the expression of LPS- and Aβ peptide-induced inflammatory mediators in astroglia
por: Ayasolla, Kamesh R, et al.
Publicado: (2005)

Cytotoxic effect of 5-aminoimidazole-4-carboxamide-1-β-4-ribofuranoside (AICAR) on childhood acute lymphoblastic leukemia (ALL) cells: implication for targeted therapy
por: Sengupta, Tapas K, et al.
Publicado: (2007)

Sirt1 Regulates Corneal Epithelial Migration by Deacetylating Cortactin
por: Lin, Yong, et al.
Publicado: (2022)

MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK
por: Hammond, Christine L., et al.
Publicado: (2021)

The effects of in ovo nicotinamide riboside dose on broiler myogenesis
por: Xu, Xiaoxing, et al.
Publicado: (2020)

Dataset on transcriptome profiling of corneal endothelium from patients with Fuchs endothelial corneal dystrophy
por: Nikitina, Anastasia S., et al.
Publicado: (2019)

The RNA m(5)C Methylase NSUN2 Modulates Corneal Epithelial Wound Healing
por: Luo, Guangying, et al.
Publicado: (2023)

Aspirin and 5-Aminoimidazole-4-carboxamide Riboside Attenuate Bovine Ephemeral Fever Virus Replication by Inhibiting BEFV-Induced Autophagy
por: Tseng, Hsu-Hung, et al.
Publicado: (2020)

Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception
por: Hegarty, Deborah M., et al.
Publicado: (2018)

Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation
por: Finburgh, Emma N., et al.
Publicado: (2023)

Loss of the Anorexic Response to Systemic 5-Aminoimidazole-4-Carboxamide-1-β-D-Ribofuranoside Administration Despite Reducing Hypothalamic AMP-Activated Protein Kinase Phosphorylation in Insulin-Deficient Rats
por: Vitzel, Kaio F., et al.
Publicado: (2013)

Data on corneal proteome and differentially expressed corneal proteins in highly myopic chicks using a data independent quantification approach
por: Kang, Byung Soo, et al.
Publicado: (2019)

Nicotinamide Riboside and Dihydronicotinic Acid Riboside Synergistically Increase Intracellular NAD(+) by Generating Dihydronicotinamide Riboside
por: Ciarlo, Eleonora, et al.
Publicado: (2022)

Snf1/AMPK promotes the formation of Kog1/Raptor-bodies to increase the activation threshold of TORC1 in budding yeast
por: Hughes Hallett, James E, et al.
Publicado: (2015)

Macrophage polarization in tissue fibrosis
por: Yang, Huidan, et al.
Publicado: (2023)

Gypenosides Protect Orbital Fibroblasts in Graves Ophthalmopathy via Anti-Inflammation and Anti-Fibrosis Effects
por: Li, Haoyu, et al.
Publicado: (2020)

Nicotinamide Riboside Alleviates Corneal and Somatic Hypersensitivity Induced by Paclitaxel in Male Rats
por: Hamity, Marta V., et al.
Publicado: (2022)

Chronic 5-Aminoimidazole-4-Carboxamide-1-β-d-Ribofuranoside Treatment Induces Phenotypic Changes in Skeletal Muscle, but Does Not Improve Disease Outcomes in the R6/2 Mouse Model of Huntington’s Disease
por: Paré, Marie-France, et al.
Publicado: (2017)

5-Amino-1-β-D-Ribofuranosyl-Imidazole-4-Carboxamide (AICAR) Reduces Peripheral Inflammation by Macrophage Phenotype Shift
por: Martin, Lisa Maria, et al.
Publicado: (2019)

Amino-acid site variability among natural and designed proteins
por: Jackson, Eleisha L., et al.
Publicado: (2013)

Dynamics of mTORC1 activation in response to amino acids
por: Manifava, Maria, et al.
Publicado: (2016)

Resilience of BST-2/Tetherin structure to single amino acid substitutions
por: Roy, Ian R., et al.
Publicado: (2019)

Dataset supporting the proteomic characterization of human corneal epithelial cells with HSV-1 infection
por: Xu, Zhi-Yi, et al.
Publicado: (2019)

Hypoxia-induced factor and its role in liver fibrosis
por: Mohammad Omar, Jan, et al.
Publicado: (2022)

Oxidation of cellular amino acid pools leads to cytotoxic mistranslation of the genetic code
por: Bullwinkle, Tammy J, et al.
Publicado: (2014)

Targeted metabolomic profiles of serum amino acids and acylcarnitines related to gastric cancer
por: Li, Dehong, et al.
Publicado: (2022)

5-aminoimidazole-4-carboxamide Riboside Induces Apoptosis Through AMP-activated Protein Kinase-independent and NADPH Oxidase-dependent Pathways
por: Wi, Sae Mi, et al.
Publicado: (2014)

miR-200a-3p overexpression alleviates diabetic cardiomyopathy injury in mice by regulating autophagy through the FOXO3/Mst1/Sirt3/AMPK axis
por: You, Penghua, et al.
Publicado: (2023)

One-step Metabolomics: Carbohydrates, Organic and Amino Acids Quantified in a Single Procedure
por: Shoemaker, James D.
Publicado: (2010)

Four sesquiterpene glycosides from loquat (Eriobotrya japonica) leaf ameliorates palmitic acid-induced insulin resistance and lipid accumulation in HepG2 Cells via AMPK signaling pathway
por: Li, Jiawei, et al.
Publicado: (2020)

A 22-amino-acid peptide regulates tight junctions through occludin and cell apoptosis
por: Zhu, Maoying, et al.
Publicado: (2020)

Amino acids and acylcarnitine production by Chlorella vulgaris and Chlorella sorokiniana microalgae from wastewater culture
por: Ballesteros-Torres, Juan M., et al.
Publicado: (2019)

RO4929097, a Selective γ-Secretase Inhibitor, Inhibits Subretinal Fibrosis Via Suppressing Notch and ERK1/2 Signaling in Laser-Induced Mouse Model
por: Zhang, Chaoyang, et al.
Publicado: (2022)

Effects of nicotine on corneal wound healing following acute alkali burn
por: Kim, Jong Won, et al.
Publicado: (2017)

Release of protein N-glycans by effectors of a Hofmann carboxamide rearrangement
por: Kasim, Mumtaz, et al.
Publicado: (2022)

Comparative proteomics of Rhizopus delemar ATCC 20344 unravels the role of amino acid catabolism in fumarate accumulation
por: Odoni, Dorett I., et al.
Publicado: (2017)

Purification of the Cystic Fibrosis Transmembrane Conductance Regulator Protein Expressed in Saccharomyces cerevisiae
por: Pollock, Naomi, et al.
Publicado: (2014)

Inflammation and fibrosis in the coal dust-exposed lung described by confocal Raman spectroscopy
por: Wang, Wenyang, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_519lqeh96984ij35m76vo5p3dv