Cargando…

Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab’-Immunoliposomes for Gene Silencing in Breast Cancer Cells

PURPOSE: The overexpression of Her-2 in 25–30% breast cancer cases and the crosstalk between Her-2 and fatty acid synthase (FASN) establishes Her-2 as a promising target for site-directed delivery. The present study aimed to develop the novel lipid base formulations to target and inhibit the cellula...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Arif, Aljarbou, Ahmed N, Aldebasi, Yousef H, Allemailem, Khaled S, Alsahli, Mohammed A, Khan, Shamshir, Alruwetei, Abdulmohsen M, Khan, Masood A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Dove 2020
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415462/ https://www.ncbi.nlm.nih.gov/pubmed/32801705 http://dx.doi.org/10.2147/IJN.S256022

Ejemplares similares

Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice
por: Khan, Arif, et al.
Publicado: (2020)

Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Potential of Methylglyoxal-Conjugated Chitosan Nanoparticles in Treatment of Fluconazole-Resistant Candida albicans Infection in a Murine Model
por: Khan, Shaheer Hasan, et al.
Publicado: (2020)

Combination of glycosphingosomes and liposomal doxorubicin shows increased activity against dimethyl-α-benzanthracene-induced fibrosarcoma in mice
por: Khan, Masood A, et al.
Publicado: (2015)

Comparison of anti-EGFR-Fab’ conjugated immunoliposomes modified with two different conjugation linkers for siRNa delivery in SMMC-7721 cells
por: Deng, Li, et al.
Publicado: (2013)

Immunoliposomes-mediated small interfering RNA therapy: A novel approach for the treatment of cancer
por: Khan, Arif
Publicado: (2019)

Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice
por: Khan, Masood A., et al.
Publicado: (2018)

Thymoquinone Augments Cyclophosphamide-Mediated Inhibition of Cell Proliferation in Breast Cancer Cells
por: Khan, Arif, et al.
Publicado: (2019)

SATB1 siRNA-encapsulated immunoliposomes conjugated with CD44 antibodies target and eliminate gastric cancer-initiating cells
por: Yang, Feng, et al.
Publicado: (2018)

Liposome-Mediated Delivery of MERS Antigen Induces Potent Humoral and Cell-Mediated Immune Response in Mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Identification of Acetylation Sites of Fatty Acid Synthase (FASN) by Mass Spectrometry and FASN Activity Assay
por: Miao, Ting, et al.
Publicado: (2023)

Role of Curcumin in Disease Prevention and Treatment
por: Rahmani, Arshad Husain, et al.
Publicado: (2018)

Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche
por: Krohn-Grimberghe, Marvin, et al.
Publicado: (2020)

Improvement of Therapeutic Effect by Using Fab' Fragment in the Treatment of Carcinoembryonic Antigen‐positive Human Solid Tumors with Adriamycinentrapped Immunoliposomes
por: Uyama, Ichiro, et al.
Publicado: (1994)

Targeting Ovarian Cancer Cells Overexpressing CD44 with Immunoliposomes Encapsulating Glycosylated Paclitaxel
por: Khayrani, Apriliana Cahya, et al.
Publicado: (2019)

Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
por: Alrumaihi, Faris A, et al.
Publicado: (2021)

Fatty acid synthase (FASN) regulates the mitochondrial priming of cancer cells
por: Schroeder, Barbara, et al.
Publicado: (2021)

Efficient Drug Delivery of Paclitaxel Glycoside: A Novel Solubility Gradient Encapsulation into Liposomes Coupled with Immunoliposomes Preparation
por: Shigehiro, Tsukasa, et al.
Publicado: (2014)

Targeting immunoliposomes to EGFR-positive glioblastoma
por: Kasenda, B., et al.
Publicado: (2022)

Tumor specific delivery and therapy mediate by integrin β6-target immunoliposomes for β6-siRNA in colon carcinoma
por: Song, Liu, et al.
Publicado: (2016)

Structural Characterisation of the Beta-Ketoacyl-Acyl Carrier Protein Synthases, FabF and FabH, of Yersinia pestis
por: Nanson, Jeffrey D., et al.
Publicado: (2015)

Therapeutic Effect of Bilsaan, Sambucus nigra Stem Exudate, on the OVA-Induced Allergic Asthma in Mice
por: Alrumaihi, Faris, et al.
Publicado: (2020)

Variation in the Fatty Acid Synthase Gene (FASN) and Its Association with Milk Traits in Gannan Yaks
por: Shi, Bingang, et al.
Publicado: (2019)

In Vivo Anti-HIV Activity of the Heparin-Activated Serine Protease Inhibitor Antithrombin III Encapsulated in Lymph-Targeting Immunoliposomes
por: Asmal, Mohammed, et al.
Publicado: (2012)

Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis
por: Meyer, Ingmar Sören, et al.
Publicado: (2018)

Immunoliposomes for detection of rupture-prone intracranial aneurysms
por: Jahromi, Behnam Rezai, et al.
Publicado: (2023)

The Pyrazolo[3,4-d]Pyrimidine Derivative Si306 Encapsulated into Anti-GD2-Immunoliposomes as Therapeutic Treatment of Neuroblastoma
por: Rango, Enrico, et al.
Publicado: (2022)

Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice
por: Khan, Arif, et al.
Publicado: (2022)

Immunoliposomes doubly targeted to transferrin receptor and to α-synuclein
por: Loureiro, Joana A, et al.
Publicado: (2015)

Safety, Stability, and Therapeutic Efficacy of Long-Circulating TQ-Incorporated Liposomes: Implication in the Treatment of Lung Cancer
por: Khan, Arif, et al.
Publicado: (2022)

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth
por: Khan, Tayeba, et al.
Publicado: (2016)

Regulation of Pro-Inflammatory Macrophage Polarization via Lipid Nanoparticles Mediated Delivery of Anti-Prostaglandin-E2 siRNA
por: Almatroudi, Ahmad, et al.
Publicado: (2022)

Characterization of highly stable liposomal and immunoliposomal formulations of vincristine and vinblastine
por: Noble, Charles O., et al.
Publicado: (2009)

Immunoliposome-based fluorometric patulin assay by using immunomagnetic nanoparticles
por: Song, Xinjie, et al.
Publicado: (2019)

Preparation of siRNA–PLGA/Fabʹ–PLGA mixed micellar system with target cell-specific recognition
por: Hazekawa, Mai, et al.
Publicado: (2021)

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis
por: Khan, Arif, et al.
Publicado: (2021)

Single chain Fab (scFab) fragment
por: Hust, Michael, et al.
Publicado: (2007)

The fasn-1(g14ts) allele is a Gly1830Arg missense mutation in C. elegans FASN-1
por: Bai, Xiaofei, et al.
Publicado: (2020)

Safety and Therapeutic Efficacy of Thymoquinone-Loaded Liposomes against Drug-Sensitive and Drug-Resistant Acinetobacter baumannii
por: Allemailem, Khaled S., et al.
Publicado: (2021)

Safety and Prophylactic Efficacy of Liposome-Based Vaccine against the Drug-Resistant Acinetobacter baumannii in Mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_1q5gv90r78lv84eu9gm8uh38ae