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Monogenic and polygenic inheritance become instruments for clonal selection
Clonally expanded blood cells with somatic mutations (clonal hematopoiesis, CH) are commonly acquired with age and increase risk of blood cancer(1–9). The blood clones identified to date contain diverse large-scale mosaic chromosomal alterations (mCAs: deletions, duplications, and copy-neutral loss...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415571/ https://www.ncbi.nlm.nih.gov/pubmed/32581363 http://dx.doi.org/10.1038/s41586-020-2430-6 |