TETs compete with DNMT3 activity in pluripotent cells at thousands of methylated somatic enhancers

Mammalian cells stably maintain high levels of DNA methylation despite expressing both positive (DNMT3A/B) and negative (TET1–3) regulators. Here, we used wildtype and TET triple knockout human embryonic stem cells (ESCs), generated DNMT3-null as well as TET and DNMT3-null pentuple knockouts, and co...

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Detalles Bibliográficos
Autores principales: Charlton, Jocelyn, Jung, Eunmi J., Mattei, Alexandra L., Bailly, Nina, Liao, Jing, Martin, Eric J., Giesselmann, Pay, Brändl, Björn, Stamenova, Elena, Müller, Franz-Josef, Kiskinis, Evangelos, Gnirke, Andreas, Smith, Zachary D., Meissner, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415576/
https://www.ncbi.nlm.nih.gov/pubmed/32514123
http://dx.doi.org/10.1038/s41588-020-0639-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415576/
https://www.ncbi.nlm.nih.gov/pubmed/32514123
http://dx.doi.org/10.1038/s41588-020-0639-9

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