Structure of a D(2) dopamine receptor-G protein complex in a lipid membrane

The D(2) dopamine receptor (DRD2) is a therapeutic target for Parkinson’s disease(1) and antipsychotic drugs(2). DRD2 is activated by the endogenous neurotransmitter dopamine and synthetic agonist drugs such as bromocriptine(3), leading to stimulation of G(i) and inhibition of adenylyl cyclase. We u...

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Detalles Bibliográficos
Autores principales: Yin, Jie, Chen, Kuang-Yui M., Clark, Mary J., Hijazi, Mahdi, Kumari, Punita, Bai, Xiao-chen, Sunahara, Roger K., Barth, Patrick, Rosenbaum, Daniel M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415663/
https://www.ncbi.nlm.nih.gov/pubmed/32528175
http://dx.doi.org/10.1038/s41586-020-2379-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415663/
https://www.ncbi.nlm.nih.gov/pubmed/32528175
http://dx.doi.org/10.1038/s41586-020-2379-5

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