Role of nanoscale antigen organization on B-cell activation probed using DNA origami

Vaccine efficacy can be increased by arraying immunogens in multivalent form on virus-like nanoparticles to enhance B cell activation. However, the effects of antigen copy number, spacing, and affinity, as well as the dimensionality and rigidity of scaffold presentation on B cell activation remain p...

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Detalles Bibliográficos
Autores principales: Veneziano, Rémi, Moyer, Tyson J., Stone, Matthew B., Wamhoff, Eike-Christian, Read, Benjamin J., Mukherjee, Sayak, Shepherd, Tyson R., Das, Jayajit, Schief, William R., Irvine, Darrell J., Bathe, Mark
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415668/
https://www.ncbi.nlm.nih.gov/pubmed/32601450
http://dx.doi.org/10.1038/s41565-020-0719-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415668/
https://www.ncbi.nlm.nih.gov/pubmed/32601450
http://dx.doi.org/10.1038/s41565-020-0719-0

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