Cytotoxicity of fractured quartz on THP-1 human macrophages: role of the membranolytic activity of quartz and phagolysosome destabilization

The pathogenicity of quartz involves lysosomal alteration in alveolar macrophages. This event triggers the inflammatory cascade that may lead to quartz-induced silicosis and eventually lung cancer. Experiments with synthetic quartz crystals recently showed that quartz dust is cytotoxic only when the...

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Detalles Bibliográficos
Autores principales: Leinardi, Riccardo, Pavan, Cristina, Yedavally, Harita, Tomatis, Maura, Salvati, Anna, Turci, Francesco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Inorganic Compounds
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415752/
https://www.ncbi.nlm.nih.gov/pubmed/32592078
http://dx.doi.org/10.1007/s00204-020-02819-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7415752/
https://www.ncbi.nlm.nih.gov/pubmed/32592078
http://dx.doi.org/10.1007/s00204-020-02819-x

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