Structural Basis for the Activation and Target Site Specificity of CDC7 Kinase

CDC7 is an essential Ser/Thr kinase that acts upon the replicative helicase throughout the S phase of the cell cycle and is activated by DBF4. Here, we present crystal structures of a highly active human CDC7-DBF4 construct. The structures reveal a zinc-finger domain at the end of the kinase insert...

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Detalles Bibliográficos
Autores principales: Dick, Samual D., Federico, Stefania, Hughes, Siobhan M., Pye, Valerie E., O'Reilly, Nicola, Cherepanov, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416108/
https://www.ncbi.nlm.nih.gov/pubmed/32521228
http://dx.doi.org/10.1016/j.str.2020.05.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416108/
https://www.ncbi.nlm.nih.gov/pubmed/32521228
http://dx.doi.org/10.1016/j.str.2020.05.010

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