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Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate

Fructose consumption has risen dramatically in recent decades due to use of sucrose and high fructose corn syrup in beverages and processed foods(1), contributing to rising rates of obesity and non-alcoholic fatty liver disease (NAFLD)(2–4). Fructose intake triggers hepatic de novo lipogenesis (DNL)...

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Detalles Bibliográficos
Autores principales: Zhao, Steven, Jang, Cholsoon, Liu, Joyce, Uehara, Kahealani, Gilbert, Michael, Izzo, Luke, Zeng, Xianfeng, Trefely, Sophie, Fernandez, Sully, Carrer, Alessandro, Miller, Katelyn D., Schug, Zachary T., Snyder, Nathaniel W., Gade, Terence P., Titchenell, Paul M., Rabinowitz, Joshua D., Wellen, Kathryn E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416516/
https://www.ncbi.nlm.nih.gov/pubmed/32214246
http://dx.doi.org/10.1038/s41586-020-2101-7