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Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes
The human genome can be segmented into topologically associating domains (TADs), which have been proposed to spatially sequester genes and regulatory elements through chromatin looping. Interactions between TADs have also been suggested, presumably due to variable boundary positions across individua...
Autores principales: | Luppino, Jennifer M., Park, Daniel S., Nguyen, Son C., Lan, Yemin, Xu, Zhuxuan, Yunker, Rebecca, Joyce, Eric F. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416539/ https://www.ncbi.nlm.nih.gov/pubmed/32572210 http://dx.doi.org/10.1038/s41588-020-0647-9 |
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