Cargando…

Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

DNA topoisomerase II (TOP2) is required for the unwinding and decatenation of DNA through the induction of an enzyme-linked double-strand break (DSB) in one DNA molecule and passage of another intact DNA duplex through the break. Anticancer drugs targeting TOP2 (TOP2 poisons) prevent religation of t...

Descripción completa

Detalles Bibliográficos
Autores principales: Swan, Rebecca L., Poh, Luke L.K., Cowell, Ian G., Austin, Caroline A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416847/
https://www.ncbi.nlm.nih.gov/pubmed/32587095
http://dx.doi.org/10.1124/mol.119.118893