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Small Molecule Inhibitors Confirm Ubiquitin-Dependent Removal of TOP2-DNA Covalent Complexes

DNA topoisomerase II (TOP2) is required for the unwinding and decatenation of DNA through the induction of an enzyme-linked double-strand break (DSB) in one DNA molecule and passage of another intact DNA duplex through the break. Anticancer drugs targeting TOP2 (TOP2 poisons) prevent religation of t...

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Detalles Bibliográficos
Autores principales:	Swan, Rebecca L., Poh, Luke L.K., Cowell, Ian G., Austin, Caroline A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Pharmacology and Experimental Therapeutics 2020
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416847/ https://www.ncbi.nlm.nih.gov/pubmed/32587095 http://dx.doi.org/10.1124/mol.119.118893

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