Cargando…

Trans-Ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Transduction in Large Animal Eye After Intravitreal Vector Administration

PURPOSE: Electric micro-current has been shown to enhance penetration and transduction of adeno-associated viral (AAV) vectors in mouse retina after intravitreal administration. We termed this: “electric-current vector mobility (ECVM).” The present study considered whether ECVM could augment retinal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Song, Hongman, Zeng, Yong, Sardar Pasha, Sheik Pran Babu, Bush, Ronald A., Vijayasarathy, Camasamudram, Qian, Haohua, Wei, Lisa, Wiley, Henry E., Wu, Zhijian, Sieving, Paul A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7416894/ https://www.ncbi.nlm.nih.gov/pubmed/32844051 http://dx.doi.org/10.1167/tvst.9.7.28

Ejemplares similares

Trans-ocular Electric Current In Vivo Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration
por: Song, Hongman, et al.
Publicado: (2018)

Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice
por: Marangoni, Dario, et al.
Publicado: (2016)

NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice
por: Song, Hongman, et al.
Publicado: (2016)

Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography
por: Zeng, Yong, et al.
Publicado: (2016)

Rs1h(−/y) exon 3-del rat model of X-linked retinoschisis with early onset and rapid phenotype is rescued by RS1 supplementation
por: Zeng, Yong, et al.
Publicado: (2021)

Genetic Rescue of X-Linked Retinoschisis Mouse (Rs1(−/y)) Retina Induces Quiescence of the Retinal Microglial Inflammatory State Following AAV8-RS1 Gene Transfer and Identifies Gene Networks Underlying Retinal Recovery
por: Vijayasarathy, Camasamudram, et al.
Publicado: (2021)

Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome
por: Marangoni, Dario, et al.
Publicado: (2017)

Peripapillary Intravitreal Injection Improves AAV-Mediated Retinal Transduction
por: Madrakhimov, Sanjar Batirovich, et al.
Publicado: (2020)

Syngeneic AAV Pseudo-particles Potentiate Gene Transduction of AAV Vectors
por: Wang, Qizhao, et al.
Publicado: (2016)

Glycosidic enzymes enhance retinal transduction following intravitreal delivery of AAV2
por: Cehajic-Kapetanovic, Jasmina, et al.
Publicado: (2011)

Successful Transduction with AAV Vectors after Selective Depletion of Anti-AAV Antibodies by Immunoadsorption
por: Orlowski, Alejandro, et al.
Publicado: (2020)

Extending AAV Packaging Cargo through Dual Co-Transduction: Efficient Protein Trans-Splicing at Low Vector Doses
por: Ferreira, Mariana V., et al.
Publicado: (2023)

Polymers for Improving the In Vivo Transduction Efficiency of AAV2 Vectors
por: Moulay, Gilles, et al.
Publicado: (2010)

Role of Essential Metal Ions in AAV Vector-Mediated Transduction
por: Rambhai, Himanshu K., et al.
Publicado: (2020)

Quantifying transduction efficiencies of unmodified and tyrosine capsid mutant AAV vectors in vitro using two ocular cell lines
por: Ryals, Renee C., et al.
Publicado: (2011)

Cryo-EM of retinoschisin branched networks suggests an intercellular adhesive scaffold in the retina
por: Heymann, J. Bernard, et al.
Publicado: (2019)

Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors
por: Horiuchi, Makoto, et al.
Publicado: (2022)

Evaluating the transduction efficiency of systemically delivered AAV vectors in the rat nervous system
por: Yang, Olivia J., et al.
Publicado: (2023)

Intravenous immunoglobulin prevents peripheral liver transduction of intrathecally delivered AAV vectors
por: Horiuchi, Makoto, et al.
Publicado: (2022)

Gene therapy following subretinal AAV5 vector delivery is not affected by a previous intravitreal AAV5 vector administration in the partner eye
por: Li, Wensheng, et al.
Publicado: (2009)

Efficient gene transduction in pigs and macaques with the engineered AAV vector AAV.GT5 for hemophilia B gene therapy
por: Kashiwakura, Yuji, et al.
Publicado: (2023)

Targeted Expression of Retinoschisin by Retinal Bipolar Cells in XLRS Promotes Resolution of Retinoschisis Cysts Sans RS1 From Photoreceptors
por: Vijayasarathy, Camasamudram, et al.
Publicado: (2022)

Retinal cell death dependent reactive proliferative gliosis in the mouse retina
por: Sardar Pasha, Sheik Pran Babu, et al.
Publicado: (2017)

AAV-vectored base editor trans-splicing delivers dystrophin repair
por: Li, Zhen, et al.
Publicado: (2023)

Influence of Pre-existing Anti-capsid Neutralizing and Binding Antibodies on AAV Vector Transduction
por: Fitzpatrick, Zachary, et al.
Publicado: (2018)

Transduction of Salivary Gland Acinar Cells with a Novel AAV Vector 44.9
por: Di Pasquale, Giovanni, et al.
Publicado: (2020)

Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

Decreased Expression of Soluble Epoxide Hydrolase Suppresses Murine Choroidal Neovascularization
por: Park, Bomina, et al.
Publicado: (2022)

Transduction Pattern of AAVs in the Trabecular Meshwork and Anterior-Segment Structures in a Rat Model of Ocular Hypertension
por: Lee, Si Hyung, et al.
Publicado: (2019)

Systemic Delivery of Tyrosine-Mutant AAV Vectors Results in Robust Transduction of Neurons in Adult Mice
por: Iida, Asako, et al.
Publicado: (2013)

CNS-restricted Transduction and CRISPR/Cas9-mediated Gene Deletion with an Engineered AAV Vector
por: Murlidharan, Giridhar, et al.
Publicado: (2016)

Site-Directed Mutagenesis Improves the Transduction Efficiency of Capsid Library-Derived Recombinant AAV Vectors
por: Ran, Gai, et al.
Publicado: (2020)

Transduction optimization of AAV vectors for human gene therapy of glaucoma and their reversed cell entry characteristics
por: Rodriguez-Estevez, Laura, et al.
Publicado: (2019)

Double-Strand Break Repair Pathways Differentially Affect Processing and Transduction by Dual AAV Vectors
por: Maurer, Anna C., et al.
Publicado: (2023)

Correction: Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
Publicado: (2014)

Correction: Targeting Photoreceptors via Intravitreal Delivery Using Novel, Capsid-Mutated AAV Vectors
por: Kay, Christine N., et al.
Publicado: (2013)

AAV retinal transduction in a large animal model species: Comparison of a self-complementary AAV2/5 with a single-stranded AAV2/5 vector
por: Petersen-Jones, S.M., et al.
Publicado: (2009)

Corneal Transduction by Intra-Stromal Injection of AAV Vectors In Vivo in the Mouse and Ex Vivo in Human Explants
por: Hippert, Claire, et al.
Publicado: (2012)

Impact of intravenous infusion time on AAV8 vector pharmacokinetics, safety, and liver transduction in cynomolgus macaques
por: Greig, Jenny A, et al.
Publicado: (2016)

Development of optimized AAV3 serotype vectors: Mechanism of high-efficiency transduction of human liver cancer cells
por: Cheng, Binbin, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_ki51dc2bcmmma57jf4pk4g0291