Population pharmacokinetics–pharmacodynamics of sunitinib in pediatric patients with solid tumors

PURPOSE: The safety profile of sunitinib in children, including the impact of sunitinib exposure on safety endpoints, was assessed using population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PK–PD) models. METHODS: Data were from two clinical studies in 59 children with solid tumors (...

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Detalles Bibliográficos
Autores principales: Wang, Erjian, DuBois, Steven G., Wetmore, Cynthia, Khosravan, Reza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417410/
https://www.ncbi.nlm.nih.gov/pubmed/32623479
http://dx.doi.org/10.1007/s00280-020-04106-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417410/
https://www.ncbi.nlm.nih.gov/pubmed/32623479
http://dx.doi.org/10.1007/s00280-020-04106-z

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