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Population pharmacokinetics–pharmacodynamics of sunitinib in pediatric patients with solid tumors
PURPOSE: The safety profile of sunitinib in children, including the impact of sunitinib exposure on safety endpoints, was assessed using population pharmacokinetic (PK) and pharmacokinetic–pharmacodynamic (PK–PD) models. METHODS: Data were from two clinical studies in 59 children with solid tumors (...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Springer Berlin Heidelberg
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417410/ https://www.ncbi.nlm.nih.gov/pubmed/32623479 http://dx.doi.org/10.1007/s00280-020-04106-z |