Cytochrome P450 inhibition potential and initial genotoxic evaluation of 14-O-[(4,6-diaminopyrimidine-2-yl)thioacetyl] mutilin

14-O-[(4,6-Diaminopyrimidine-2-yl)thioacetyl] mutilin (DPTM) is a promising drug candidate with excellent antibacterial activity against Gram-positive bacteria. The present study was designed to characterize its Cytochrome P450 (CYP) enzymes inhibition activities and the genotoxicity with the standa...

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Detalles Bibliográficos
Autores principales: Fu, Yunxing, Yi, Yunpeng, Fan, Yuan, Shang, Ruofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417534/
https://www.ncbi.nlm.nih.gov/pubmed/32778735
http://dx.doi.org/10.1038/s41598-020-70400-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417534/
https://www.ncbi.nlm.nih.gov/pubmed/32778735
http://dx.doi.org/10.1038/s41598-020-70400-8

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