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Comparative structural analyses and nucleotide-binding characterization of the four KH domains of FUBP1

The FUBP1-FUSE complex is an essential component of a transcription molecular machinery that is necessary for tight regulation of expression of many key genes including c-Myc and p21. FUBP1 utilizes its four articulated KH modules, which function cooperatively, for FUSE nucleotide binding. To unders...

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Detalles Bibliográficos
Autores principales: Ni, Xiaomin, Knapp, Stefan, Chaikuad, Apirat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417555/
https://www.ncbi.nlm.nih.gov/pubmed/32778776
http://dx.doi.org/10.1038/s41598-020-69832-z