Cleavage of human tau at Asp421 inhibits hyperphosphorylated tau induced pathology in a Drosophila model

Hyperphosphorylated and truncated tau variants are enriched in neuropathological aggregates in diseases known as tauopathies. However, whether the interaction of these posttranslational modifications affects tau toxicity as a whole remains unresolved. By expressing human tau with disease-related Ser...

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Detalles Bibliográficos
Autores principales: Chi, Hao, Sun, Lee, Shiu, Ren-Huei, Han, Rui, Hsieh, Chien-Ping, Wei, Tzu-Min, Lo, Chung-Chuan, Chang, Hui-Yun, Sang, Tzu-Kang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417559/
https://www.ncbi.nlm.nih.gov/pubmed/32778728
http://dx.doi.org/10.1038/s41598-020-70423-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417559/
https://www.ncbi.nlm.nih.gov/pubmed/32778728
http://dx.doi.org/10.1038/s41598-020-70423-1

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