Antibody-secreting cell destiny emerges during the initial stages of B-cell activation

Upon stimulation, B cells assume heterogeneous cell fates, with only a fraction differentiating into antibody-secreting cells (ASC). Here we investigate B cell fate programming and heterogeneity during ASC differentiation using T cell-independent models. We find that maximal ASC induction requires a...

Descripción completa

Detalles Bibliográficos
Autores principales: Scharer, Christopher D., Patterson, Dillon G., Mi, Tian, Price, Madeline J., Hicks, Sakeenah L., Boss, Jeremy M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417592/
https://www.ncbi.nlm.nih.gov/pubmed/32778653
http://dx.doi.org/10.1038/s41467-020-17798-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417592/
https://www.ncbi.nlm.nih.gov/pubmed/32778653
http://dx.doi.org/10.1038/s41467-020-17798-x

Ejemplares similares