Thiol-ene Enabled Chemical Synthesis of Truncated S-Lipidated Teixobactin Analogs

Herein is described the introduction of lipid moieties onto a simplified teixobactin pharmacophore using a modified Cysteine Lipidation on a Peptide or Amino acid (CLipPA) technique, whereby cysteine was substituted for 3-mercaptopropionic acid (3-MPA). A truncated teixobactin analog was prepared wi...

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Detalles Bibliográficos
Autores principales: Yim, Victor V., Cameron, Alan J., Kavianinia, Iman, Harris, Paul W. R., Brimble, Margaret A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417771/
https://www.ncbi.nlm.nih.gov/pubmed/32850619
http://dx.doi.org/10.3389/fchem.2020.00568

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417771/
https://www.ncbi.nlm.nih.gov/pubmed/32850619
http://dx.doi.org/10.3389/fchem.2020.00568

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