Localised and sustained intradermal delivery of methotrexate using nanocrystal-loaded microneedle arrays: Potential for enhanced treatment of psoriasis

Methotrexate (MTX), typically used as its sodium salt (MTX Na), is a first-line treatments for moderate to severe psoriasis, showing good efficacy. However, its systemic administration is associated with many side effects. Intradermal delivery into psoriatic tissue could offer an alternative approac...

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Detalles Bibliográficos
Autores principales: Tekko, Ismaiel A., Permana, Andi Dian, Vora, Lalitkumar, Hatahet, Taher, McCarthy, Helen O., Donnelly, Ryan F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science B.V 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417809/
https://www.ncbi.nlm.nih.gov/pubmed/32679177
http://dx.doi.org/10.1016/j.ejps.2020.105469

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417809/
https://www.ncbi.nlm.nih.gov/pubmed/32679177
http://dx.doi.org/10.1016/j.ejps.2020.105469

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