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Glucose 6-phosphate dehydrogenase inhibition sensitizes melanoma cells to metformin treatment
Most cancer cells exacerbate the pentose phosphate pathway (PPP) to enhance biosynthetic precursors and antioxidant defenses. Metformin, which is used as a first-line oral drug for the treatment of type 2 diabetes, has been proposed to inhibit the malignant progression of different types of cancers....
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Neoplasia Press
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417947/ https://www.ncbi.nlm.nih.gov/pubmed/32781368 http://dx.doi.org/10.1016/j.tranon.2020.100842 |