Glucose 6-phosphate dehydrogenase inhibition sensitizes melanoma cells to metformin treatment

Most cancer cells exacerbate the pentose phosphate pathway (PPP) to enhance biosynthetic precursors and antioxidant defenses. Metformin, which is used as a first-line oral drug for the treatment of type 2 diabetes, has been proposed to inhibit the malignant progression of different types of cancers....

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Detalles Bibliográficos
Autores principales: Arbe, María Florencia, Agnetti, Lucrecia, Breininger, Elizabeth, Glikin, Gerardo Claudio, Finocchiaro, Liliana María Elena, Villaverde, Marcela Solange
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2020
Materias:
Original article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7417947/
https://www.ncbi.nlm.nih.gov/pubmed/32781368
http://dx.doi.org/10.1016/j.tranon.2020.100842

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