P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease

The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative diseases...

Descripción completa

Detalles Bibliográficos
Autores principales: Farmer, Kathleen M., Ghag, Gaurav, Puangmalai, Nicha, Montalbano, Mauro, Bhatt, Nemil, Kayed, Rakez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418370/
https://www.ncbi.nlm.nih.gov/pubmed/32778161
http://dx.doi.org/10.1186/s40478-020-01012-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418370/
https://www.ncbi.nlm.nih.gov/pubmed/32778161
http://dx.doi.org/10.1186/s40478-020-01012-6

Ejemplares similares