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P53 aggregation, interactions with tau, and impaired DNA damage response in Alzheimer’s disease
The transcription factor, p53, is critical for many important cellular functions involved in genome integrity, including cell cycle control, DNA damage response, and apoptosis. Disruption of p53 results in a wide range of disorders including cancer, metabolic diseases, and neurodegenerative diseases...
Autores principales: | Farmer, Kathleen M., Ghag, Gaurav, Puangmalai, Nicha, Montalbano, Mauro, Bhatt, Nemil, Kayed, Rakez |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418370/ https://www.ncbi.nlm.nih.gov/pubmed/32778161 http://dx.doi.org/10.1186/s40478-020-01012-6 |
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