Likelihood of Nonspecific Activity of Gapmer Antisense Oligonucleotides Is Associated with Relative Hybridization Free Energy

Reduction of matched and nearly complementary unintended transcripts was evaluated for 96 antisense oligonucleotides (ASOs) and 832 nearly matched unintended transcripts. The ASOs were 16–20 nucleotide “gapmers” with a gap of 8–10 DNA residues and 2′-O-methoxy-ethyl or constrained-ethyl substitution...

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Detalles Bibliográficos
Autores principales: Watt, Andrew T., Swayze, Grant, Swayze, Eric E., Freier, Susan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mary Ann Liebert, Inc., publishers 2020
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418465/
https://www.ncbi.nlm.nih.gov/pubmed/32125928
http://dx.doi.org/10.1089/nat.2020.0847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418465/
https://www.ncbi.nlm.nih.gov/pubmed/32125928
http://dx.doi.org/10.1089/nat.2020.0847

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