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Vitamin C is a source of oxoaldehyde and glycative stress in age‐related cataract and neurodegenerative diseases
Oxoaldehyde stress has recently emerged as a major source of tissue damage in aging and age‐related diseases. The prevailing mechanism involves methylglyoxal production during glycolysis and modification of arginine residues through the formation of methylglyoxal hydroimidazolones (MG‐H1). We now te...
Autores principales: | Fan, Xingjun, Sell, David R., Hao, Caili, Liu, Sabrina, Wang, Benlian, Wesson, Daniel W., Siedlak, Sandra, Zhu, Xiongwei, Kavanagh, Terrance J., Harrison, Fiona E., Monnier, Vincent M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418511/ https://www.ncbi.nlm.nih.gov/pubmed/32567221 http://dx.doi.org/10.1111/acel.13176 |
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