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Predicting antigen specificity of single T cells based on TCR CDR3 regions

It has recently become possible to simultaneously assay T‐cell specificity with respect to large sets of antigens and the T‐cell receptor sequence in high‐throughput single‐cell experiments. Leveraging this new type of data, we propose and benchmark a collection of deep learning architectures to mod...

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Detalles Bibliográficos
Autores principales: Fischer, David S, Wu, Yihan, Schubert, Benjamin, Theis, Fabian J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418512/
https://www.ncbi.nlm.nih.gov/pubmed/32779888
http://dx.doi.org/10.15252/msb.20199416