Deep Mutational Scanning of SARS-CoV-2 Receptor Binding Domain Reveals Constraints on Folding and ACE2 Binding

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The receptor binding domain (RBD) of the SARS-CoV-2 spike glycoprotein mediates viral attachment to ACE2 receptor and is a major determinant of host range and a dominant target of neutralizing antibodies. Here, we experimentally measure how all amino acid mutations to the RBD affect expression of fo...

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Detalles Bibliográficos
Autores principales: Starr, Tyler N., Greaney, Allison J., Hilton, Sarah K., Ellis, Daniel, Crawford, Katharine H.D., Dingens, Adam S., Navarro, Mary Jane, Bowen, John E., Tortorici, M. Alejandra, Walls, Alexandra C., King, Neil P., Veesler, David, Bloom, Jesse D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418704/
https://www.ncbi.nlm.nih.gov/pubmed/32841599
http://dx.doi.org/10.1016/j.cell.2020.08.012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418704/
https://www.ncbi.nlm.nih.gov/pubmed/32841599
http://dx.doi.org/10.1016/j.cell.2020.08.012

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