Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors

Mostrar otras versiones (1)

We report the identification of three structurally diverse compounds – compound 4, GC376, and MAC-5576 – as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for des...

Descripción completa

Detalles Bibliográficos
Autores principales: Iketani, Sho, Forouhar, Farhad, Liu, Hengrui, Hong, Seo Jung, Lin, Fang-Yu, Nair, Manoj S., Zask, Arie, Huang, Yaoxing, Xing, Li, Stockwell, Brent R., Chavez, Alejandro, Ho, David D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418712/
https://www.ncbi.nlm.nih.gov/pubmed/32793898
http://dx.doi.org/10.1101/2020.08.03.235291

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418712/
https://www.ncbi.nlm.nih.gov/pubmed/32793898
http://dx.doi.org/10.1101/2020.08.03.235291

Ejemplares similares