Arginase inhibition by (−)-Epicatechin reverses endothelial cell aging

Endothelial dysfunction (EnD) occurs with aging and endothelial nitric oxide (NO) production by NO synthase (NOS) can be impaired. Low NO levels have been linked to increased arginase (Ar) activity as Ar competes with NOS for L-arginine. The inhibition of Ar activity can reverse EnD and (−)-epicatec...

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Detalles Bibliográficos
Autores principales: Garate-Carrillo, Alejandra, Navarrete-Yañez, Viridiana, Ortiz-Vilchis, Pilar, Guevara, Gustavo, Castillo, Carmen, Mendoza-Lorenzo, Patricia, Ceballos, Guillermo, Ortiz-Flores, Miguel, Najera, Nayelli, Bustamante-Pozo, Moises Muratt, Rubio-Gayosso, Ivan, Villarreal, Francisco, Ramirez-Sanchez, Israel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2020
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418791/
https://www.ncbi.nlm.nih.gov/pubmed/32795514
http://dx.doi.org/10.1016/j.ejphar.2020.173442

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7418791/
https://www.ncbi.nlm.nih.gov/pubmed/32795514
http://dx.doi.org/10.1016/j.ejphar.2020.173442

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