KN3014, a piperidine-containing small compound, inhibits auto-secretion of IL-1β from PBMCs in a patient with Muckle–Wells syndrome

NLRP3, an intracellular pattern recognition receptor, recognizes numerous pathogens and/or its own damage-associated molecules, and forms complexes with the adaptor protein ASC. These complexes constitute the NLRP3 inflammasome, a platform for processing interleukin (IL)-1β and/or IL-18. Several NLR...

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Detalles Bibliográficos
Autores principales: Kaneko, Naoe, Kurata, Mie, Yamamoto, Toshihiro, Shigemura, Tomonari, Agematsu, Kazunaga, Yamazaki, Takashi, Takeda, Hiroyuki, Sawasaki, Tatsuya, Koga, Tomohiro, Kawakami, Atsushi, Yachie, Akihiro, Migita, Kiyoshi, Yoshiura, Koh-ichiro, Urano, Takeshi, Masumoto, Junya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419506/
https://www.ncbi.nlm.nih.gov/pubmed/32782316
http://dx.doi.org/10.1038/s41598-020-70513-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7419506/
https://www.ncbi.nlm.nih.gov/pubmed/32782316
http://dx.doi.org/10.1038/s41598-020-70513-0

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